Anti-Human/Mouse/Rat Phospho-c-Kit (Tyr721) Polyclonal Antibody

Phospho-c-Kit (Tyr721)多克隆抗体

Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Phosphorylates PIK3R1, PLCG1, SH2B2/APS and CBL. Activates the AKT1 signaling pathway by phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Activated KIT also transmits signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3, STAT5A and STAT5B. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KIT signaling is modulated by protein phosphatases, and by rapid internalization and degradation of the receptor. Activated KIT promotes phosphorylation of the protein phosphatases PTPN6/SHP-1 and PTPRU, and of the transcription factors STAT1, STAT3, STAT5A and STAT5B. Promotes phosphorylation of PIK3R1, CBL, CRK (isoform Crk-II), LYN, MAPK1/ERK2 and/or MAPK3/ERK1, PLCG1, SRC and SHC1.
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基本信息

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货号 PA01530
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human c-Kit around the phosphorylation site of Tyr721
特异性 Isoform 1 and isoform 2 are detected in spermatogonia and Leydig cells. Isoform 3 is detected in round spermatids, elongating spermatids and spermatozoa (at protein level). Widely expressed. Detected in the hematopoietic system, the gastrointestinal system, in melanocytes and in germ cells.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P10721
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, ELISA 1:10000
配方
应用范围 WB,ELISA
别名 C Kit,c-Kit,c-Kit Ligand,CD117,Kit,Kit Ligand,KIT oncogene,KIT proto oncogene receptor tyrosine kinase,KIT,Mast cell growth factor receptor,Mast/stem cell growth factor receptor Kit,MGF,p145 c-kit,PBT,Piebald trait protein,Proto oncogene c Kit,Proto oncogene tyrosine protein kinase Kit,Proto-oncogene c-Kit,SCF Receptor,SCFR,soluble KIT variant 1,Steel Factor Receptor,Stem cell factor receptor,tyrosine protein kinase Kit,Tyrosine-protein kinase Kit,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene homolog,v kit Hardy Zuckerman 4 feline sarcoma viral oncogene like protein,v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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