The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream gene, TAX1BP3.P2RX5 (Purinergic Receptor P2X 5) is a Protein Coding gene. Diseases associated with P2RX5 include Cystinosis. Among its related pathways are Calcium signaling pathway and CREB Pathway. GO annotations related to this gene include transmembrane signaling receptor activity and purinergic nucleotide receptor activity. An important paralog of this gene is P2RX5-TAX1BP3.