Anti-Human/Mouse/Rat MKP-1 Polyclonal Antibody

MKP-1多克隆抗体

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.
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基本信息

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货号 PA11154
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human DUSP1
特异性 Expressed at high levels in the lung, liver placenta and pancreas. Moderate levels seen in the heart and skeletal muscle. Lower levels found in the brain and kidney.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P28562
浓度 0.4 mg/mL
推荐稀释度 WB 1:200-1:1000, IHC 1:25-1:100
配方
应用范围 WB,IHC,ELISA
别名 CL 100,CL100,Dual Specificity Phosphatase 1,Dual specificity protein phosphatase 1,Dual specificity protein phosphatase hVH1,DUS1,DUSP 1,Dusp1,HVH1,MAP kinase phosphatase 1,Mitogen-activated protein kinase phosphatase 1,MKP-1,MKP1,Protein tyrosine phosphatase CL100,Protein-tyrosine phosphatase CL100,PTPN10,Serine/threonine specific protein phosphatase,VH1
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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