Anti-Human/Mouse/Rat MERTK/TYRO3 Polyclonal Antibody

MERTK/TYRO3多克隆抗体

MERTK is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).MERTK (MER Proto-Oncogene, Tyrosine Kinase) is a Protein Coding gene. Diseases associated with MERTK include Retinitis Pigmentosa 38 and Mertk-Related Retinitis Pigmentosa.An important paralog of this gene is AXL. TYRO3 (TYRO3 Protein Tyrosine Kinase) is a Protein Coding gene. Diseases associated with TYRO3 include External Ear Carcinoma and Lymphocytic Choriomeningitis. Among its related pathways are GPCR Pathway and Nanog in Mammalian ESC Pluripotency. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is AXL.
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基本信息

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货号 PA04941
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human MerTK/Tyro3 around the non-phosphorylation site of Tyr749/681.
特异性 MERTK is Not expressed in normal B- and T-lymphocytes but is expressed in numerous neoplastic B- and T-cell lines. Highly expressed in testis, ovary, prostate, lung, and kidney, with lower expression in spleen, small intestine, colon, and liver.TYRO3 isAbundant in the brain and lower levels in other tissues.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:20000
配方
应用范围 WB,IHC-p,ELISA
别名 MERTK,MER,Tyrosine-protein kinase Mer,Proto-oncogene c-Mer,Receptor tyrosine kinase MerTK,TYRO3,BYK,DTK,RSE,SKY,Tyrosine-protein kinase receptor TYRO3,Tyrosine-protein kinase DTK,Tyrosine-protein kinase RSE,Tyrosine-protein kin
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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