Anti-Human/Mouse/Rat LRP2 Polyclonal Antibody

LRP2多克隆抗体

The protein encoded by this gene, low density lipoprotein-related protein 2 (LRP2) or megalin, is a multi-ligand endocytic receptor that is expressed in many different tissues but primarily in absorptive epithilial tissues such as the kidney. This glycoprotein has a large amino-terminal extracellular domain, a single transmembrane domain, and a short carboxy-terminal cytoplasmic tail. The extracellular ligand-binding-domains bind diverse macromolecules including albumin, apolipoproteins B and E, and lipoprotein lipase. The LRP2 protein is critical for the reuptake of numerous ligands, including lipoproteins, sterols, vitamin-binding proteins, and hormones. This protein also has a role in cell-signaling; extracellular ligands include parathyroid horomones and the morphogen sonic hedgehog while cytosolic ligands include MAP kinase scaffold proteins and JNK interacting proteins. Recycling of this membrane receptor is regulated by phosphorylation of its cytoplasmic domain. Mutations in this gene cause Donnai-Barrow syndrome (DBS) and facio-oculoacoustico-renal syndrome (FOAR).
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基本信息

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货号 PA07984
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human LRP2
特异性 Absorptive epithelia, including renal proximal tubules.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P98164
浓度 0.3 mg/mL
推荐稀释度 IHC 1:15-1:50
配方
应用范围 IHC,ELISA
别名 Calcium sensor protein,DBS,Glycoprotein 330,gp330,Heymann nephritis antigen homolog,Low-density lipoprotein receptor-related protein 2,LRP-2,Lrp2,LRP2,Megalin
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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