LONP1(Lon protease homolog,mitochondrial) is also named as LONP,LONHS,HLON,LON,PRSS15,PIM1,MGC1498 and belongs to the peptidase S16 family. It seems to play a major role in the elimination of oxidatively modified proteins in the mitochondrial matrix. LONP1,also a nuclearly encoded and mitochondrially located stress-responsive protease,is involved in heme-mediated ALAS-1 turnover. It recognizes specific surface determinants or folds,initiates proteolysis at solvent-accessible sites,and generates unfolded polypeptides that are then processively degraded.