KIFAP3,also known as KIF3AP or KAP3,is a novel KIF3A/3B-associated protein. It binds to the tail domain of KIF3A/3B and may play a role in regulating the binding of KIF3A/3B to cargoes. Recently it has been reported that mutation within the KIFAP3 gene is associated with decreased KIFAP3 expression and increased survival in sporadic ALS,which makes it a potential target for ALS therapy. KIFAP3 has also been identified as the target of mir-130a.