Anti-Human/Mouse/Rat KI67 Monoclonal Antibody

KI67单克隆抗体

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).
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基本信息

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货号 MA01778
规格 100μl
宿主 Mouse
免疫原 Synthetic Peptide
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆 8K5
Uniprot P46013
浓度 1mg/mL
推荐稀释度 IHC 1:100-1:300, IF 1:50-200
配方
应用范围 IHC-p,IF
别名 Antigen identified by monoclonal Ki 67,Antigen identified by monoclonal Ki-67,Antigen KI-67,Antigen KI67,Antigen Ki67,KI67,KIA,Marker of proliferation Ki-67,MIB 1,MIB,MKI67,PPP1R105,Proliferation marker protein Ki-67,Proliferation related Ki 67 antigen,Protein phosphatase 1 regulatory subunit 105,RP11-380J17.2
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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