Anti-Human/Mouse/Rat KDM4D Polyclonal Antibody

KDM4D多克隆抗体

JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.
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基本信息

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货号 PA11964
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human KDM4D
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q6B0I6
浓度 0.2 mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:50-1:200
配方
应用范围 WB,IHC,ELISA
别名 JHD3D,JHDM3D,JmjC domain-containing histone demethylation protein 3D,Jumonji domain-containing protein 2D,Kdm4d,KDM4D,Lysine-specific demethylase 4D
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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