Anti-Human/Mouse/Rat GRM3 Polyclonal Antibody

GRM3多克隆抗体

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. 
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基本信息

数据文档 查看数据文档
货号 PA12255
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human GRM3
特异性 Detected in brain cortex, thalamus, subthalamic nucleus, substantia nigra, hypothalamus, hippocampus, corpus callosum, caudate nucleus and amygdala.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q14832
浓度 0.2 mg/mL
推荐稀释度 IHC 1:50-1:200
配方
应用范围 IHC,ELISA
别名 GLUR3,Glutamate metabotropic receptor 3,Glutamate receptor metabotropic 3,GPRC1C,GRM3,GRM3,Metabotropic glutamate receptor 3,MGlu3,mGluR3
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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