The GNL1 gene, identified in the human major histocompatibility complex class I region, shows a high degree of similarity with its mouse counterpart. The GNL1 gene is located less than 2 kb centromeric to HLA-E, in the same transcriptional orientation. GNL1 is telomeric to HLA-B and HLA-C.GNL1 (G Protein Nucleolar 1 (Putative)) is a Protein Coding gene. GO annotations related to this gene include GTP binding and structural molecule activity. An important paralog of this gene is LSG1.