Guanine nucleotide-binding protein G(z) subunit alpha is a protein that in humans is encoded by the GNAZgene. The protein encoded by this gene is a member of a G protein subfamily that mediates signal transduction in pertussis toxin-insensitive systems. This encoded protein may play a role in maintaining the ionic balance of perilymphatic and endolymphatic cochlear fluids. GNAZ has been shown to interact with EYA2, RGS20 and RGS19.