Anti-Human/Mouse/Rat GIT2 Polyclonal Antibody

GIT2多克隆抗体

This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.GIT2 (GIT ArfGAP 2) is a Protein Coding gene. Among its related pathways are Adhesion and Focal Adhesion. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is GIT1.
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基本信息

数据文档 查看数据文档
货号 PA04197
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from the Internal region of human GIT2
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q14161
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:50-1:200, ELISA 1:5000-1:20000
配方
应用范围 WB,IHC-p,ELISA
别名 ARF GAP GIT2,ARF GTPase activating protein GIT2,ARF GTPase-activating protein GIT2,CAT 2,CAT-2,CAT2,Cool associated tyrosine phosphorylated protein 2,Cool interacting tyrosine phosphorylated protein 2,Cool-interacting tyrosine-phosphorylated protein 2,DKFZp686G01261,G protein coupled receptor kinase interacting ArfGAP 2,G protein coupled receptor kinase interactor 2,G protein-coupled receptor kinase-interactor 2,GIT 2,GIT2,GIT2,GRK interacting protein 2,GRK-interacting protein 2,KIAA0148,MGC760
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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