GABBR2 (Gamma-Aminobutyric Acid Type B Receptor Subunit 2) is a Protein Coding gene. Diseases associated with GABBR2 include Nicotine Dependence, Protection Against and Sensory Neuropathy Type 1. Among its related pathways are GABAergic synapse and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and G-protein coupled GABA receptor activity. An important paralog of this gene is GABBR1.The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.