Fibulin-5,also known as EVEC and DANCE,is a extracellular matrix glycoprotein,secreted by various cell types such as vascular smooth muscle cells,fibroblasts and endothelial cells. Structurally,Fibulin-5 contains an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. FBLN5 mutations have been described in patients with age-related macular degeneration,as well as being involved in Charcot-Marie-Tooth neuropathies.