Anti-Human/Mouse/Rat FANCD2 Polyclonal Antibody

FANCD2多克隆抗体

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group D2. This protein is monoubiquinated in response to DNA damage, resulting in its localization to nuclear foci with other proteins (BRCA1 AND BRCA2) involved in homology-directed DNA repair. Alternative splicing results in multiple transcript variants.
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基本信息

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货号 PA03888
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human FANCD2 around the non-phosphorylation site of Ser222.
特异性 Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q9BXW9
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, ELISA 1:10000
配方
应用范围 WB,IHC-p,ELISA
别名 DKFZp762A223,FA 4,FA D2,FA4,FAC D2,FACD 2,FACD,FACD2,FACD2,FAD,FAD2,FANC D2,FANCD 2,FANCD,FANCD2,FANCONI ANEMIA COMPLEMENTATION GROUP D,Fanconi anemia complementation group D2,Fanconi anemia group D2 protein,FANCONI PANCYTOPENIA TYPE 4,FLJ23826,OTTHUMP00000158853,OTTHUMP00000207925,Protein FACD2,Type 4 Fanconi pancytopenia
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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