Anti-Human/Mouse/Rat ERBB3 Polyclonal Antibody

ERBB3多克隆抗体

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
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基本信息

数据文档 查看数据文档
货号 PA11733
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human ERBB3
特异性 Epithelial tissues and brain.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P21860
浓度 0.3 mg/mL
推荐稀释度 IHC 1:25-1:100
配方
应用范围 IHC,ELISA
别名 c erbB 3,c erbB3,Erb b2 receptor tyrosine kinase 3,ErbB 3,ERBB3,ERBB3 protein,erbB3 S,ERBB3,Glial growth factor receptor,HER 3,HER3,Human epidermal growth factor receptor 3,LCCS2,MDA BF 1,MGC88033,p180 ErbB3,p45 sErbB3,p85 sErbB3,proto-oncogene-like protein c ErbB 3,proto-oncogene-like protein c ErbB3,Proto-oncogene-like protein c-ErbB-3,Receptor tyrosine protein kinase erbB 3,Receptor tyrosine protein kinase erbB3,Receptor tyrosine-protein kinase erbB-3,Tyrosine kinase type cell surface receptor HER3,Tyrosine kinase-type cell surface receptor HER3,v erb b2 avian erythroblastic leukemia viral oncogene homolog 3,v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian),v erb b2 erythroblastic leukemia viral oncogene homolog 3
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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