Anti-Human/Mouse/Rat ER beta Polyclonal Antibody

ER beta多克隆抗体

This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized.
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基本信息

数据文档 查看数据文档
货号 PA09396
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human ESR2
特异性 Isoform beta-1 is expressed in testis and ovary, and at a lower level in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, prostate, colon, bone marrow, mammary gland and uterus. Also found in uterine bone, breast, and ovarian tumor cell lines, but not in colon and liver tumors. Isoform beta-2 is expressed in spleen, thymus, testis and ovary and at a lower level in skeletal muscle, prostate, colon, small intestine, leukocytes, bone marrow, mammary gland and uterus. Isoform beta-3 is found in testis. Isoform beta-4 is expressed in testis, and at a lower level in spleen, thymus, ovary, mammary gland and uterus. Isoform beta-5 is expressed in testis, placenta, skeletal muscle, spleen and leukocytes, and at a lower level in heart, lung, liver, kidney, pancreas, thymus, prostate, colon, small intestine, bone marrow, mammary gland and uterus. Not expressed in brain.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q92731
浓度 0.5 mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:50-1:200
配方
应用范围 WB,IHC,ELISA
别名 ER BETA,ER-beta,Erb,ESR B,ESR BETA,ESR2,ESR2,ESRB,ESTRB,estrogen nuclear receptor beta variant a,estrogen nuclear receptor beta variant b,estrogen receptor 2 (ER beta),Estrogen receptor 2,estrogen receptor beta 4,Estrogen receptor beta,NR3A2,Nuclear receptor subfamily 3 group A member 2
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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