Anti-Human/Mouse/Rat EPHA1 Polyclonal Antibody

EPHA1多克隆抗体

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds with a low affinity EFNA3 and EFNA4 and with a high affinity to EFNA1 which most probably constitutes its cognate/functional ligand. Upon activation by EFNA1 induces cell attachment to the extracellular matrix inhibiting cell spreading and motility through regulation of ILK and downstream RHOA and RAC. Plays also a role in angiogenesis and regulates cell proliferation. May play a role in apoptosis.
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基本信息

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货号 PA04290
规格 100μl
宿主 Rabbit
免疫原 Synthetic Peptide
特异性 Overexpressed in several carcinomas.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P21709
浓度 1mg/mL
推荐稀释度 WB 1:1000-2000, IHC 1:100-200
配方
应用范围 WB,IHC-p
别名 EPH,EPH receptor A1,EPH tyrosine kinase 1,EPH tyrosine kinase,Epha1,EPHA1,Ephrin receptor Eph A1,Ephrin type A receptor 1,Ephrin type-A receptor 1,EPHT 1,EPHT,EPHT1,Erythropoietin producing hepatoma amplified sequence,Erythropoietin-producing hepatoma receptor,Esk,hEpha1,MGC163163,Oncogene EPH,Soluble EPHA1 variant 1,Soluble EPHA1 variant 2,Tyrosine protein kinase receptor EPH,Tyrosine-protein kinase receptor EPH
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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