Enolases are cytoplasmic glycolytic enzymes that may be involved in differentiation. Three enolase isoenzymes,alpha,beta and gamma ,phaare present in mammalian cells. The alpha form is expressed in most tissues,whereas the beta form is expressed in muscle tissue. The gamma enolase (ENO2),a homodimer,is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs inneural tissue during development.