Anti-Human/Mouse/Rat DIO2 Polyclonal Antibody

DIO2多克隆抗体

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
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基本信息

数据文档 查看数据文档
货号 PA09821
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human DIO2
特异性 Heart, skeletal muscle, placenta, fetal brain and several regions of the adult brain.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q92813
浓度 0.9 mg/mL
推荐稀释度 IHC 1:25-1:100
配方
应用范围 IHC,ELISA
别名 5DII,D2,Deiodinase,iodothyronine,type II,DIO2,DIOII,EC 1.97.1.10,IOD2,ITDI2,SelY,Thyroxine deiodinase,type II,TXDI2,Type 2 DI,Type 2 iodothyronine deiodinase,Type II 5' deiodinase,Type II iodothyronine deiodinase,Type-II 5''-deiodinase
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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