Anti-Human/Mouse/Rat DHCR24 Polyclonal Antibody

DHCR24多克隆抗体

This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
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基本信息

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货号 PA10500
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human DHCR24
特异性 Highly expressed in brain and adrenal gland with moderate expression in liver, lung, spleen, prostate and spinal cord. Low expression in heart, uterus and prostate. Undetectable in blood cells. In the brain, strongly expressed in cortical regions, substantia nigra, caudate nucleus, hippocampus, medulla oblongata and pons. In brains affected by Alzheimer disease, expression in the inferior temporal lobe is substantially lower than in the frontal cortex.
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q15392
浓度 0.6 mg/mL
推荐稀释度 IHC 1:25-1:100
配方
应用范围 IHC,ELISA
别名 24 dehydrocholesterol reductase,24-dehydrocholesterol reductase,3 beta hydroxysterol delta 24 reductase,3-beta-hydroxysterol delta-24-reductase,DCE,Delta(24)-sterol reductase,Desmosterol to cholesterol enzyme,DHC24,Dhcr24,Diminuto dwarf1 homolog,Diminuto/dwarf1 homolog,KIAA0018,Nbla03646,Seladin-1,SELADIN1,Selective AD indicator 1,Selective Alzheimer's Disease Indicator 1
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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