Anti-Human/Mouse/Rat DDB1 Polyclonal Antibody

DDB1多克隆抗体

The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However, it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition, Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q, but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
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基本信息

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货号 PA11370
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human DDB1
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot Q16531
浓度 0.1 mg/mL
推荐稀释度 WB 1:200-1:1000, IHC 1:10-1:100
配方
应用范围 WB,IHC,ELISA
别名 XPE, DDBA, XAP1, XPCE, XPE-BF, UV-DDB1
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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