The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain.DAB1 (DAB1, Reelin Adaptor Protein) is a Protein Coding gene. Diseases associated with DAB1 include Lissencephaly With Cerebellar Hypoplasia and Lissencephaly. Among its related pathways are Lipoprotein metabolism and Neuroscience. GO annotations related to this gene include phosphatidylinositol 3-kinase binding. An important paralog of this gene is DAB2.