CISH (Cytokine Inducible SH2 Containing Protein) is a Protein Coding gene. Diseases associated with CISH include Bacteremia and Mycobacterium Tuberculosis, Susceptibility To Mycobacterium Tuberculosis, Protection Against, Included. Among its related pathways are Development EPO-induced Jak-STAT pathway and Common Cytokine Receptor Gamma-Chain Family Signaling Pathways. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is SOCS2.The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.