Anti-Human/Mouse/Rat CDK4 Polyclonal Antibody

CDK4多克隆抗体

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.
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基本信息

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货号 PA11717
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human CDK4
特异性
亚型 IgG
反应性 Human,Mouse,Rat
克隆
Uniprot P11802
浓度 0.4 mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:10-1:50
配方
应用范围 WB,IHC,ELISA
别名 Cdk 4,cdk4,CDK4 protein,CDK4,Cell division kinase 4,Cell division protein kinase 4,CMM 3,CMM3,Crk3,Cyclin dependent kinase 4,Cyclin-dependent kinase 4,Melanoma cutaneous malignant 3,MGC14458,p34 cdk4,PSK J3,PSK-J3
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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