This gene encodes a member of the plexin family. Plexins are transmembrane receptors for semaphorins, a large family of proteins that regulate axon guidance, cell motility and migration, and the immune response. The encoded protein and its ligand regulate melanocyte adhesion, and viral semaphorins may modulate the immune response by binding to this receptor. The encoded protein may be a tumor suppressor protein for melanoma. Alternatively spliced transcript variants have been observed for this gene. PLXNC1 (Plexin C1) is a Protein Coding gene. Diseases associated with PLXNC1 include Polycystic Kidney And Hepatic Disease. Among its related pathways are Developmental Biology and Semaphorin interactions. GO annotations related to this gene include receptor binding and receptor activity. An important paralog of this gene is PLXND1.