CD206,also named as MMR,CLEC13D and MRC1,is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. CD206 has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses,bacteria,and fungi so that they can be neutralized by phagocytic engulfment. CD206 is a 170 kDa transmembrane protein which contains 5 domains: an amino-terminal cysteine-rich region,a fibronectin type II repeat,a series of eight tandem lectin-like carbohydrate recognition domains (responsible for the recognition of mannose and fucose),a transmembrane domain,and an intracellular carboxy-terminal tail. It is expressed on most tissue macrophages,in vitro derived dendritic cells,lymphatic and sinusoidal endothelia. This antibody recognizes the intracellular carboxy-terminal part of CD206 and MRC1L1.