This gene encodes a protein that is highly similar to the rat CaM-KII inhibitory protein, an inhibitor of calcium/calmodulin-dependent protein kinase II (CAMKII). CAMKII regulates numerous physiological functions, including neuronal synaptic plasticity through the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate (AMPA) receptors. Studies of the similar protein in rat suggest that this protein may function as a negative regulator of CaM-KII and may act to inhibit the phosphorylation of AMPA receptors. CAMK2N2 (Calcium/Calmodulin Dependent Protein Kinase II Inhibitor 2) is a Protein Coding gene. GO annotations related to this gene include protein kinase binding and calcium-dependent protein kinase inhibitor activity. An important paralog of this gene is CAMK2N1.