This gene reduces the metastatic potential, but not the tumorogenicity, of human breast cancer and melanoma cell lines. The protein encoded by this gene localizes primarily to the nucleus and is a component of the mSin3a family of histone deacetylase complexes (HDAC). The protein contains two coiled-coil motifs and several imperfect leucine zipper motifs. Alternative splicing results in two transcript variants encoding different isoforms.BRMS1 (Breast Cancer Metastasis Suppressor 1) is a Protein Coding gene. Diseases associated with BRMS1 include Breast Cancer. Among its related pathways are Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 and Chromatin organization. GO annotations related to this gene include histone deacetylase binding and histone deacetylase activity. An important paralog of this gene is BRMS1L.