BRE,also named as BRCC45,is a death receptor-associated antiapoptotic protein,which is also involved in DNA-damage repair,and K63-specific deubiquitination. BRE and its XIAP-sustaining mechanism could represent novel targets for anti-cancer therapy. BRE may regulate TNF-alpha signaling through its interactions with TNFRSF1A. It plays a role in homeostasis or cellular differentiation in cells of neural,epithelial and germline origins. BRE gene has four isoforms with MW 42-47 kDa.