This gene encodes a nuclear protein with a homeobox DNA-binding domain that functions as a transcriptional regulator involved in cell-type differentiation and development. Preferential methylation of this gene's promoter is associated with advanced-stage neuroblastoma tumors.ALX3 (ALX Homeobox 3) is a Protein Coding gene. Diseases associated with ALX3 include Frontonasal Dysplasia 1 and Basal Encephalocele. GO annotations related to this gene include sequence-specific DNA binding. An important paralog of this gene is ALX4.