Anti-Human /Mouse /Rat AKR1C3 Polyclonal Antibody

AKR1C3多克隆抗体

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene.
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基本信息

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货号 PA03228
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human AKR1C3
特异性 Expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. The dominant HSD in prostate and mammary gland. In the prostate, higher levels in epithelial cells than in stromal cells. In the brain, expressed in medulla, spinal cord, frontotemporal lobes, thalamus, subthalamic nuclei and amygdala. Weaker expression in the hippocampus, substantia nigra and caudate.
亚型 IgG
反应性 Human ,Mouse ,Rat
克隆
Uniprot P42330
浓度 0.7 mg/mL
推荐稀释度 WB 1:500-1:2000
配方
应用范围 WB
别名 17 beta HSD 5,17 beta hydroxysteroid dehydrogenase type 5,17-beta-HSD 5,17-beta-hydroxysteroid dehydrogenase type 5,2-dihydrobenzene-1,2-diol dehydrogenase,20-alpha-hydroxysteroid dehydrogenase,3 alpha hydroxysteroid dehydrogenase type II,3-alpha-HSD type 2,3-alpha-HSD type II,3-alpha-HSD type II,brain,3-alpha-hydroxysteroid dehydrogenase type 2,AK1C3,AKR1 C3,Akr1c18,AKR1C3,Aldo keto reductase family 1 member C3,Aldo-keto reductase family 1 member C3,brain,Chlordecone reductase,Chlordecone reductase homolog HAKRb,DD-3,DD3,DDH1,DDX,Dihydrodiol dehydrogenase 3,Dihydrodiol dehydrogenase type I,Dihydrodiol dehydrogenase X,HA1753,HAKRB,HAKRe,hluPGFS,HSD17B5,Indanol dehydrogenase,KIAA0119,PGFS,Prostaglandin F synthase,Testosterone 17-beta-dehydrogenase 5,Trans-1,Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase,Type IIb 3 alpha hydroxysteroid dehydrogenase
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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