Homeodomain proteins are sequence-specific transcription factors that share a highly conserved DNA-binding domain and play fundamental roles in cell proliferation, differentiation, and death. PKNOX2 belongs to the TALE (3-amino acid loop extension) class of homeodomain proteins characterized by a 3-amino acid extension between alpha helices 1 and 2 within the homeodomain.PKNOX2 (PBX/Knotted 1 Homeobox 2) is a Protein Coding gene. Diseases associated with PKNOX2 include Substance Dependence and Hydrolethalus Syndrome. GO annotations related to this gene include sequence-specific DNA binding and actin monomer binding. An important paralog of this gene is PKNOX1.