Anti-Human/Mouse Phospho-TBC1D4 (Thr642) Polyclonal Antibody

Phospho-TBC1D4 (Thr642)多克隆抗体

TBC1 domain family member 4 (TBC1D4), also designated AS160, can be insulin- and/or AKT1-induced. Insulin-stimulated phosphorylation is required for GLUT4 translocation. TBC1D4 may play a role as a GTPase activating protein for proteins in the Rab family. It is expressed primarily in skeletal muscle and heart, as well as spleen, lymph node and leukocytes. Defects in the TBC1D4 gene may cause atopic dermatitis (AD), sometimes referred to as eczema, an atopic chronic skin disease. The skin of affected individuals reacts to irritants or allergens and becomes red, flaky and itchy. The skin is also more vulnerable to inflammations, and symptoms can grow or disappear over time.
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基本信息

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货号 PA03878
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from human TBC1D4 around the phosphorylation site of Thr642
特异性 Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level). Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T cells from patients with atopic dermatitis.
亚型 IgG
反应性 Human,Mouse
克隆
Uniprot O60343
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300, IF 1:200-1:1000, ELISA 1:5000
配方
应用范围 WB,IHC-p,IF,ELISA
别名 Acrg embryonic lethality (mouse) minimal region ortholog,Acrg embryonic lethality minimal region ortholog,Acrg embryonic lethality mouse minimal region ortholog,Akt substrate of 160 kDa,AS 160,AS160,BUB2,CDC16,KIAA0603,NIDDM5,TBC (Tre 2 BUB2 CDC16) domain containing protein,TBC Tre 2 BUB2 CDC16 domain containing protein,TBC1 D4,TBC1 domain family member 4,Tbc1d4,TBCD4,Tre-2
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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