Anti-Human/Mouse p53RFP Polyclonal Antibody

p53RFP多克隆抗体

p53 is the most commonly mutated gene in human cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of human sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjugating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle.
价格: 2507.4元
  • Buy 5 for ¥2382.03 each and save 5%
  • Buy 21 for ¥2256.66 each and save 10%
  • Buy 31 for ¥2131.29 each and save 15%
  • Buy 51 for

基本信息

数据文档 查看数据文档
货号 PA12013
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human RNF144B
特异性 Broadly expressed, with lowest levels in brain and thymus, and highest levels detectable in heart, ovary and testis.
亚型 IgG
反应性 Human,Mouse
克隆
Uniprot Q7Z419
浓度 0.4 mg/mL
推荐稀释度 WB 1:200-1:1000, IHC 1:50-1:200
配方
应用范围 WB,IHC,ELISA
别名 bA528A10.3,E3 ubiquitin protein ligase RNF144B,E3 ubiquitin-protein ligase RNF144B,IBR domain containing 2,IBR domain containing protein 2,IBR domain-containing protein 2,IBRDC 2,IBRDC2,KIAA0161,MGC71786,OTTHUMP00000016079,OTTHUMP00000016080,OTTHUMP00000039360,p53 inducible RING finger protein,p53-inducible RING finger protein,p53RFP,PIR2,R144B,Ring finger 144B,RING finger protein 144B,RNF 144B,RNF144B
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

©2024 武汉天正源生物科技有限公司版权所有. SiteMap