NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction.NEIL3 (Nei Like DNA Glycosylase 3) is a Protein Coding gene. Among its related pathways are Telomere C-strand (Lagging Strand) Synthesis. GO annotations related to this gene include nucleic acid binding and single-stranded DNA binding. An important paralog of this gene is NEIL2.