Krüppel-like factor 15 is a protein that in humans is encoded by the KLF15 gene in the Krüppel-like factorfamily. KLF15, a kidney-enriched Krüppel-like factor, is a transcriptonal activator that binds the CLCNKA promoter. KLF15, which is a nuclear protein, is expressed primarily in liver, heart, skeletal muscle and kidney tissues but is not detected in lymphoid tissues or bone marrow. It is an important regulator of GLUT4 in both adipose and muscle tissues.