Anti-Human/Mouse IRAK1BP1 Polyclonal Antibody

IRAK1BP1多克隆抗体

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
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基本信息

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货号 PA12372
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human IRAK1BP1
特异性
亚型 IgG
反应性 Human,Mouse
克隆
Uniprot Q5VVH5
浓度 0.3 mg/mL
推荐稀释度 WB 1:200-1:1000, IHC 1:50-1:200
配方
应用范围 WB,IHC,ELISA
别名 ActA binding protein 3,AIP70,Interleukin 1 receptor associated kinase 1 binding protein 1,IRAK1-binding protein 1,Signaling molecule that associates with Pelle-like kinase,SIMPL
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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