GA-binding protein subunit beta-2 is a protein that in humans is encoded by the GABPB2 gene. The GABPB variant containing a C-terminal leucine zipper motif, which they called GABP-beta, can homodimerize and form a transcriptionally active heterotetrameric complex with GABPA. The variant lacking this motif, which they called GABP-gamma, can form heterodimers but cannot form transcriptionally active heterotetramers with GABPA.