Anti-Human/Mouse Frizzled 7 Polyclonal Antibody

Frizzled 7多克隆抗体

Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues.
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基本信息

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货号 PA04091
规格 100μl
宿主 Rabbit
免疫原 Synthesized peptide derived from the N-terminal region of human Frizzled-7
特异性 High expression in adult skeletal muscle and fetal kidney, followed by fetal lung, adult heart, brain, and placenta. Specifically expressed in squamous cell esophageal carcinomas.
亚型 IgG
反应性 Human,Mouse
克隆
Uniprot O75084
浓度 1mg/mL
推荐稀释度 WB 1:500-1:2000, IF 1:100-1:300, ELISA 1:20000
配方
应用范围 WB,IF,ELISA
别名 Frizzled 7,seven transmembrane spanning receptor,frizzled class receptor 7,Frizzled drosophila homolog of 7,Frizzled family receptor 7,Frizzled homolog 7,Frizzled-7,Frizzled7,Fz 7,Fz-7,Fz7,FZD 7,FZD7,FZD7,FzE 3,FzE3,hFz 7,hFz7,Homolog of Drosophila Frizzled 7,OTTHUMP00000163742
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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