Fibromodulin (FMOD),an extracellular matrix protein,belongs to the small leucine-rich proteoglycan family. Fibromodulin is a collagen-binding protein present in many types of connective tissues,e.g. cartilage,tendon,skin,sclera and cornea . It is involved in fibrillogenesis,cell adhesion,and cytokine activity modulation . Fibromodulin may participate in the assembly of the extracellular matrix as it interacts with type I and type II collagen fibrils and inhibits fibrillogenesis in vitro. It may also regulate TGF-beta activities by sequestering TGF-beta into the extracellular matrix. The calculated molecular mass of fibromodulin is 43 kDa,extracellular fibromodulin appears as one single band of 59 kDa due to glycosylation .