ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene.ERF (ETS2 Repressor Factor) is a Protein Coding gene. Diseases associated with ERF include Craniosynostosis 4 and Kleeblattschaedel Syndrome. Among its related pathways are Cellular Senescence and Oncogene Induced Senescence. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription corepressor activity. An important paralog of this gene is ETV3.