Anti-Human/Mouse CYFIP2 Polyclonal Antibody

CYFIP2多克隆抗体

CYFIP2 (Cytoplasmic FMR1-interacting protein 2, p53-inducible protein 121) is a 1,278 amino acid protein encoded by the human gene CYFIP2. CYFIP2 belongs to the CYFIP family and is involved in T-cell adhesion and p53-dependent induction of apoptosis. It interacts with FMR1, FXR1 and FXR2 and is a component of the WAVE1 complex composed of Abi-2, CYFIP2, C3orf10/HSPC300, NAP125 and WASF1/WAVE1. Upon binding to activated Rac 1, CYFIP2 causes the complex to dissociate, releasing activated WASF1. The CYFIP2 promoter contains a p53-responsive element that confers p53 binding as well as transcriptional activation of a heterologous reporter. Induced expression of CYFIP2 is sufficient for caspase activation and cellular apoptosis, reminiscent of p53 activation.
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基本信息

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货号 PA12296
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human CYFIP2
特异性
亚型 IgG
反应性 Human,Mouse
克隆
Uniprot Q96F07
浓度 0.6 mg/mL
推荐稀释度 WB 1:200-1:1000, IHC 1:50-1:200
配方
应用范围 WB,IHC,ELISA
别名 CYFP2,cytoplasmic FMR1 interacting protein 2,KIAA1168,p53 inducible protein,p53-inducible protein 121,PIR121
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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