Anti-Human/Mouse BCR Polyclonal Antibody

BCR多克隆抗体

A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
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基本信息

数据文档 查看数据文档
货号 PA10462
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human BCR
特异性
亚型 IgG
反应性 Human,Mouse
克隆
Uniprot P11274
浓度 0.5 mg/mL
推荐稀释度 IHC 1:25-1:100
配方
应用范围 IHC,ELISA
别名 ALL,bcr,BCR/ABL FUSION GENE,INCLUDED,BCR/FGFR1 chimera protein,BCR/FGFR1 FUSION GENE,INCLUDED,BCR/PDGFRA FUSION GENE,INCLUDED,BCR,BCR1,Breakpoint cluster region,Breakpoint cluster region protein,CML,D22S11,D22S662,FGFR1/BCR chimera protein,PHL,Renal carcinoma antigen NY-REN-26
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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