This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants.PTGR1 (Prostaglandin Reductase 1) is a Protein Coding gene. Among its related pathways are Arachidonic acid metabolism and NRF2 pathway. GO annotations related to this gene include oxidoreductase activity and 13-prostaglandin reductase activity. An important paralog of this gene is PTGR2.