Anti-Human LEPR Polyclonal Antibody

LEPR多克隆抗体

The protein encoded by this gene belongs to the gp130 family of cytokine receptors that are known to stimulate gene transcription via activation of cytosolic STAT proteins. This protein is a receptor for leptin (an adipocyte-specific hormone that regulates body weight), and is involved in the regulation of fat metabolism, as well as in a novel hematopoietic pathway that is required for normal lymphopoiesis. Mutations in this gene have been associated with obesity and pituitary dysfunction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. It is noteworthy that this gene and LEPROT gene (GeneID:54741) share the same promoter and the first 2 exons, however, encode distinct proteins (PMID:9207021).
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基本信息

数据文档 查看数据文档
货号 PA11032
规格 100μl
宿主 Rabbit
免疫原 Synthetic peptide of human LEPR
特异性 Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
亚型 IgG
反应性 Human
克隆
Uniprot P48357
浓度 0.3 mg/mL
推荐稀释度 IHC 1:25-1:100
配方
应用范围 IHC,ELISA
别名 CD 295,CD295,CD295 antigen,Db,Fa,HuB219,LEP R,LEP-R,LEPR,LEPR,LEPRD,Leptin receptor,Leptin receptor fatty,Leptin receptor gene related protein,Leptin receptor precursor,Leptin receptor precursor,OB R gene related protein,OB receptor,OB-R,OB-RGRP,obl,Obr
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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