Anti-Human KLK6 Polyclonal Antibody

KLK6多克隆抗体

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene.
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基本信息

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货号 PA11948
规格 100μl
宿主 Rabbit
免疫原 Recombinant protein of human KLK6
特异性 In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors.
亚型 IgG
反应性 Human
克隆
Uniprot Q92876
浓度 0.4 mg/mL
推荐稀释度 WB 1:500-1:2000, IHC 1:100-1:300
配方
应用范围 WB,IHC,ELISA
别名 Bssp,hK 6,hK6,Kallikrein 6 precursor,Kallikrein related peptidase 6,Kallikrein-6,Kallikrein6,KLK 6,Klk 7,KLK 9,Klk29,Klk6,KLK6,Klk7,KLK9,MGC9355,mGK 1,mGK1,MSP,Neurosin,Protease M,Protease serine 18,Protease serine 9,PRSS 18,PRSS 9,PRSS18,PRSS9,Serine protease 18,Serine protease 9,SP 59,SP59,Tissue kallikrein,TK,Zyme
保存条件 冻干产品: 2 - 8°C保存5年; 液体: -20°C保存2年.
注意 仅用于科学研究, 不能用于疾病诊断.

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