Gelsolin (GSN) is an actin binding protein that regulates actin-severing/depolymerizing in a calcium dependent manner,and acts as a multifunctional regulator for cell metabolism and survival. Gelsolin exists in two isoforms: a cytoplasmic gelsolin (cGSN; 80-90 kDa) and a plasma gelsolin (pGSN; 93 kDa),differing at N terminal residues. Decreased levels of pGSN are strongly associated with human diseases,such as,acute liver injury,major trauma,myocardial infarction,inflammation,lung injury,rheumatoid arthritis,hemodialysis,multiple sclerosis,Alzheimer's disease.