Fibrinogen is a soluble plasma glycoprotein synthesized in the liver. It is composed of two sets of three structurally different subunits: alpha (FGA),beta (FGB),gamma (FGG). Fibrinogen is converted by thrombin into fibrin during blood coagulation. Fibrinogen and fibrin play overlapping roles in blood clotting,fibrinolysis,cellular and matrix interactions,the inflammatory response,wound healing,and neoplasia . FGG is the gamma chain of fibrinogen. Mutations in the gene of FGG lead to several disorders,including dysfibrinogenemia,hypofibrinogenemia and thrombophilia.